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Image Search Results
Journal: Nature neuroscience
Article Title: Synaptic diversity enables temporal coding of coincident multi-sensory inputs in single neurons
doi: 10.1038/nn.3974
Figure Lengend Snippet: Identification of MF-GC input types using K-Means clustering analysis of EPSC properties. ( a ) Diagram of a parasagittal slice of cerebellar vermis, showing the vestibular region (lobule X) where single MF-GC connections were studied using extracellular stimulation and postsynaptic whole-cell voltage-clamp recording of unitary EPSCs. ( b ) Unitary EPSCs from individual trials (gray traces) and mean (black trace) from two example MF-GC synapses (arrowheads indicate timing of stimulation). EPSC peak amplitude, coefficient of variation of the peak amplitude (CV), and paired-pulse ratio (PPR) were used for cluster analysis. ( c ) Plot of the two principal components (PrinC) calculated using the K-Means clustering algorithm on 259 inputs. Data points are experiments in which blind stimulation was performed (n = 83 inputs). Black circles are the cluster centers with an area proportional to the number of points inside the cluster. The percentage of inputs in each cluster are indicated (%). Color-code is used throughout all figures referring to input groups. ( d ) Averaged traces, calculated from each cluster or “Group” (n inputs are 19, 44, 81, 74, and 41 for groups 1-5). ( e ) Summary plots of EPSC metrics according to group for all 259 inputs. Box plots represent quantiles (minimum, 25 %, median, 75 % and maximum values).
Article Snippet: An unsupervised
Techniques: